As stated elsewhere, I am on a combined cancer therapy of daily 5mg Everolimus and 14mg Lenvatinib. The major side effect that I have already commented on is nausea. Last time, I quickly resolved it by taking Ondansetron. Just make sure you have a supply of laxatives if you do the same.
I thought it might be helpful to list some of the other side effects, so that you know what to expect. It would also be useful to know if you have a different experience. Please leave a comment if you do. Generally, I am tolerating the drugs quite well and the side effects are not having too much of an effect on my life.
Tiredness and Weakness
Both drugs come with the common side effect of feeling tired or weak. Lenvatinib comes with the common side effect of trouble sleeping. I am having all these to some extent. Sleeping is variable. I have some very good nights, but some bad ones too where I am just lying in bed for hours not sleeping. Overall, I am not drastically sleep-deprived, but would like a bit more sleep. I am trying to combat these effects with more exercise. But exercise is a bit of a challenge when you are feeling tired and weak.
Itching
Again, both drugs have the common side effect of itching skin and that affects me. I do not notice it too badly during the day, but it is sometimes really annoying at night.
Red Hands and Feet
Both list redness of the hands and feet as being quite common side effects, It affects my feet more than my hands and doesn’t trouble me. My feet are not unduly sore or anything like that.
Changed Taste
I am finding that a lot of things taste different from before. Not for the better, either. Oranges taste bitter. Good red wine tastes worse that the cheapest red wine you can buy. I didn’t drink that much anyway, but it is a pity not to be able to enjoy it. Also texture matters more. I stopped liking steamed potatoes, but am fine with mashed or fried.
Mouth Sores
I am getting occasional mouth sores, which are a listed side effect of Everolimus. They are not really worrying so far, but would be if they got much worse. I have just started using Bonjela on them and that helps.
That is about all that is affecting me that I notice. There are potential effects on the kidney and liver, which would be detectable by blood test. I have blood tests every month and am told that the results are satisfactory soo far. I will report it if anything changes